It is unclear what caused their symptoms, but officers and physicians in the CDC's Epidemic Intelligence Service on the team, said they found it suspicious they all feel sick simultaneously and with similar symptoms.
The team began to feel better once they exited East Palestine, the CDC official told CNN.
In a separate incident in February, two EPA contractors working at the site reported symptoms linked to strong odors. They were told to leave the area and their symptoms eased, so they went back to work at the site the same day.
The community ACE (after chemical exposure) survey has been taken by 514 residents via a healthcare provider or at the Ohio Department of Health's Assessment Clinic in East Palestine.
The clinic offered free health checks for people affected by the disaster and Gov. Mike DeWine announced last week it would stay open permanently.
Wade Lovett, 40, has suffered breathing difficulties and his previously low voice now sounds high-pitched and squeaky. He has had to go off work sick as a result
A giant plume of smoke from the aftermath of the incident could be seen from miles away
The top four symptoms reported in the survey were: headache (74 percent), anxiety (61 percent), coughing (53 percent) and fatigue (53 percent).
Half of residents also reported a stuffy nose and irritated or burning skin.
Residents have been reporting symptoms ever since the derailment occurred at the start of the month.