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Plastic heterogeneously affects social systems – notably human health and local and global economic climates. Here we discuss illustrative examples within the benefits and burdens of stage for this plastic lifecycle (e.g., macroplastic production, consumption, recycling). We look for the good things about communities and stakeholders are principally economic, whereas burdens fall largely on human health. Furthermore, the economic benefits of plastic hardly ever applied to ease or mitigate the health burdens it creates, amplifying the disconnect between who benefits and who is burdened. In a instances, social enterprises in low-wealth areas collect and recycle waste, creating a market for upcycled goods. While such endeavors generate local socioeconomic benefits, they perpetuate a status quo in which the burden of responsibility for waste management falls on downstream communities, associated with on producers who have generated far larger economic benefits. While the traditional cost-benefit analyses that inform decision-making disproportionately weigh economic benefits over the indirect, frequently unquantifiable, costs of health burdens, we stress the drive to is the health burdens of plastic to all impacted stakeholders across all plastic life stages in policy product. We therefore urge the Intergovernmental Negotiating Committee to take into account all available knowledge relating to the deleterious regarding plastic surrounding the entire plastic lifecycle while drafting the upcoming international global plastic agreement.

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